You observe that Pd(OAc)₂ with a pyridine-sulfoximine ligand enables β-C(sp³)–H arylation of a ketone without any directing group. Propose a catalytic cycle and explain the role of the ligand in preventing ketone enolization.
Does your mechanism violate Bredt's rule? Does it require a 4-membered ring transition state? Does it explain the stereochemistry given in the product? If yes, write it in pen. If no, revert to the "electron bookkeeping" step. advanced organic chemistry practice problems
A compound with formula C₈H₁₄O shows no optical activity but exists as two diastereomers. Propose structures consistent with these facts. Does it require a 4-membered ring transition state
Consider the anomeric effect in a pyranose ring. If no, revert to the "electron bookkeeping" step
A compound with formula C₆H₁₀O₃ shows a strong IR band at 1735 cm⁻¹ and a singlet at δ 3.7 (3H) in ¹H NMR, plus a multiplet at δ 2.6 (4H). Propose a structure.
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