Following her success at the Miss Universe pageant, Sen transitioned into acting. One of her early and most notable roles was in the film "Dastak" (1996), which marked her Bollywood debut. She has since appeared in a wide range of films across various languages, including Hindi, Bengali, and Telugu.
Sen made her acting debut in 1996 with the Bollywood film "Dastak," which was followed by a string of successful movies, including "Tezaab" (1999), "Bhool Bhulaiyaa" (2003), and "Main Hoon Na" (2004). Her performances earned her critical acclaim and numerous awards, including the Filmfare Award for Best Supporting Actress.
In addition to her professional accomplishments, Sen has been in the spotlight for her personal life, including her relationships and family. She has been a devoted mother to her two sons, Riaan and Aryan, whom she adopted in 2010 and 2013, respectively.