Ensure your Mastercam USB dongle is plugged directly into the motherboard (not a front-panel port) and that you have disabled USB selective suspend in your Power Options.
Navigate to the following path: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Class\36fc9e60-c465-11cf-8056-444553540000 mastercam x72022 virtual usb bus error 39 updated