This error is a classic relic of early-2010s game engines clashing with contemporary graphics drivers, high refresh rates, and Windows updates. If you are staring at this error instead of blasting Kleer skeletons, don't worry. Below is a detailed, step-by-step guide to forcing Serious Sam 3 to cooperate.
You can also try adding -safe to launch with minimal video settings. 4. Graphics Driver and DPI Settings serious sam 3 cannot set display mode
If the game launches successfully, you might need to set your graphics options again. Do not restore the old file. This error is a classic relic of early-2010s