Here are the most effective ways to fix this issue, ordered by likelihood of success:
If updating Uplay doesn't work, try reinstalling it: how to fix far cry 4 uplay-r1-loader64.dll missing
The "uplay_r1_loader64.dll missing" error in is usually caused by your antivirus software incorrectly flagging and quarantining the file, as it is a critical component for the game's launcher Step 1: Restore the File from Windows Security Here are the most effective ways to fix
This process identifies the missing DLL and downloads a fresh, clean copy. Method 3: Manual Installation clean copy. Method 3: Manual Installation