Madden NFL 12 on the RPCS3 emulator can be a smooth experience with the right tweaks, though performance varies heavily depending on your CPU strength. While the official RPCS3 Wiki currently recommends default settings for general compatibility, users on community forums like Operation Sports have identified specific configurations that stabilize framerates and resolve audio issues.
Auto (or 8x/16x for sharper textures if your GPU is strong) madden 12 rpcs3 settings