The message "Sorry, this application cannot run under a virtual machine" in Dead Space 3 is a false positive caused by outdated DRM conflicting with modern Windows security features. In 99% of cases, solves the problem. For the remaining 1%, the noVM DLL or switching to the Steam release is the answer.
Are you using a , a Cloud PC (Shadow) , or a Standard Windows PC ? Have you already tried disabling Hyper-V in your settings? Which launcher are you using (EA App, Steam, or Origin)? The message "Sorry, this application cannot run under