Based on a true story, "Girl, Interrupted" follows Susanna Kaysen (Winona Ryder), a young woman who is sent to a psychiatric hospital in the 1960s. She meets a group of quirky and troubled girls, including Lisa (Angelina Jolie), Polly (Whoopi Goldberg), and Natalie (Elizabeth Mos), who challenge her perceptions of herself and the world around her. As Susanna navigates her own mental health and the unorthodox therapy methods of Dr. Wick (Christopher Meloni), she must confront the dark secrets and complexities of her own life.

A charismatic, rebellious sociopath who dominates the ward and exerts a powerful, often dangerous influence on the other girls. Jolie’s powerhouse performance earned her an Academy Award .

Inside the ward, Susanna discovers a "parallel world" inhabited by a group of women who become her only community: